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This drug is rarely used as a first-line treatment for depression. That means it’s usually only prescribed when other medications have not worked for you or caused bothersome side effects. Tetracyclic antidepressants, like Maprotiline (Ludiomil), are used to treat depression and anxiety. They also work by balancing neurotransmitters to ease symptoms of depression. Symptoms of anxiety disorders can be managed with medications, such as benzodiazepines and SSRIs.

There are some things you can do to make SSRIs work better for you. Your doctor may start you on a lower dose and increase it gradually to the full dose. Side effects you have when you start an SSRI medication may also fade after a few weeks. Some people, especially children and young adults (up to age 25), may be more likely to have suicidal thoughts when they take SSRIs. Studies show that when compared to results from taking a placebo, chances of having suicidal thoughts doubled (from 1%-2% to 2%-4%) when taking any kind of antidepressant, including an SSRI.

Discontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away. Get professional help from an online addiction and mental health counselor from BetterHelp. ADAA promotes privacy and encourages participants to keep personal information such as address and telephone number from being posted. Similarly, do not ask for personal information from other participants. Any comments that ask for telephone, address, venlafaxine hcl er e-mail, surveys and research studies will not be approved for posting.

Except for 1 week, this significant advantage was maintained throughout the study. I think we should use certain terms less (e.g. drugs, medicines, herbs), and be more scientific and less biased with our descriptions. All these things are psychotropic substances (meaning they affect the brain in some way), which to me is a more scientific term with no positive or negative connotation. It is only good or bad for a given individual … sometimes both (e.g. if it has a positive effect but also negative side effects). Some people think "natural" products or herbs are safer, which is not always true. Many over the counter products are more dangerous to overdose on than prescription meds.

TCAs work by blocking the reuptake of serotonin and noradrenaline, increasing their levels in the brain. There is also an association between benzodiazepine use and an increased risk of being unable to learn or remember new information or do certain physical and cognitive tasks. These side effects normally reduce once the drug clears the body. They're usually preferred over other antidepressants, as they cause fewer side effects. Once you're ready to come off antidepressants, your doctor will probably recommend reducing your dose gradually over several weeks – or longer, if you have been taking them for a long time.

The drug is available as an intravenous infusion or an intranasal product called Spravato (esketamine). Sometimes, treatment with one medication isn’t enough to help with symptoms of depression. One option to consider that may help you find the best antidepressant medication and minimize side effects is pharmacogenetic testing.